MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival
نویسندگان
چکیده
منابع مشابه
MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival.
The molecular mechanisms that underlie T-cell quiescence are poorly understood. In the present study, we report a primary immunodeficiency phenotype associated with MST1 deficiency and primarily characterized by a progressive loss of naive T cells. The in vivo consequences include recurrent bacterial and viral infections and autoimmune manifestations. MST1-deficient T cells poorly expressed the...
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ژورنال
عنوان ژورنال: Blood
سال: 2012
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2011-09-378364